Department of Medicine
 Medical Grand Rounds

SRC AS A TARGET IN ANTIESTROGEN RESISTANT BREAST CANCER
May 28, 2008
 University of Miami, School of Medicine
 
Joyce Slingerland, M.D., Ph.D.
Professor of Medicine
Division of Hematology/Oncology
Department of Medicine

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Src as a target in antiestrogen resistant breast cancer

Upon completion of this activity, physicians should be able to:
1. Review regulation of cell cycle by estrogen
2. Review role of p27
3. Mechanism of Src action on p27
4. P27 as mediator of Tamoxifen and AI arrest
5. Preclinical data showing Src inhibitor synergizes with Aromatase inhibitor



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