2005 Proceedings

The Proceedings of the 2005 Miami Nature Biotechnology Winter Symposium

SIGNAL TRANSDUCTION IN CANCER, Volume 16
February 5-9, 2005, Miami, Florida 

The authors with links are the presenters of the Short Reports for posters.
*Invited Speakers are marked with an asterisk. 

A

Ahing, A.M.
PROTEOMIC PROFILING OF SIGNAL TRANSDUCTION PATHWAYS AND DISEASE
*Ahn, N., 30, 107 
Alexander, D.R., 72, 98
Ali, S. 
Allauzen, S., 116
EXPRESSION OF MUC4/SIALOMUCIN COMPLEX (SMC) IN CERVICAL CANCER
Almeida, Z., 42, 129
Ahmad, F. 
Andreka, P., 105
Arce, M., 85 
Arkhipov, S., 36, 83
RATIONAL DISCOVERY AND DEVELOPMENT OF TARGETED THERAPIES
Arnold, L.D., 26, 74
Arnold, M., 64 
Arulanandam, R., 135
Asgeirsdottir, S.A., 122, 136 
Attwell, S., 131
Auersperg, N., 94, 134 
Augorn, K., 80

B

Balkan, W., 57 
Barnes, L., 125 
Barnett, S., 79 
Barrios-Rodiles, M., 69 
Bartlett, J.M.S. 
Basler, K., 67 
Bastien, J. 
YES-ASSOCIATED PROTEIN, A TRANSCRIPTION FACTOR MODULATOR, IS A POTENTIAL TUMOR SUPPRESSOR
Basu, S. 
Bateman, A., 61 
Bergmann, A., 123 
Bernard, C., 115 
Bernardini, M.S. 
Berra, E., 45 
Bishop, J.S., 68 
Bishopric, N.H., 105 
Black, E., 56 
Bognar, Z., 105 
Boise, L.H., 88 
Borchers, C., 124 
Borysov, S.I., 58 
Bose, R., 69 
Boutin, J.A. 
Bowie, J.U., 68 
NOVEL ASSAY KITS FOR INTEGRIN-MEDIATED CELL ADHESION TO EXTRACELLULAR MATRIX PROTEINS
Boyer, M.J., 42, 130
Brautigan, D.L., 87 
NOVEL PHOSPHATASE PHLPPbeta, IS A POTENTIAL TUMOR SUPPRESSOR THAT NEGATIVELY REGULATES THE P13K/AKT PATHWAY
Brognard, J., 24, 36, 50 
NOVEL PHOSPHATASE PHLPPβ, IS A POTENTIAL TUMOR SUPPRESSOR THAT NEGATIVELY REGULATES THE PI3K/Akt PATHWAY
Brognard, J., 24, 36, 50 
Brown, N.R., 75 
Bulin, B., 118 
NEGATIVE REGULATION OF SRC TRANSFORMING POTENTIAL IN NORMAL HUMAN EPITHELIAL CELLS
Burbridge, M.F. 
STRUCTURE-GUIDED FRAGMENT-BASED LEAD GENERATION FOR ONCOLOGY TARGETS
*Burley, S.K., 30, 108 
Burnstein, K.L., 57, 72 

C

Callebaut, I., 117 
OLIGONUCLEOTIDE MICROARRAY PROFILING OF INSULIN MRNA RESPONSE IN LIVER CELLS
Campbell, W.G. 
Caohuy, H., 106 
Carraway, C.A.C., 70, 137 
Carraway, K.L., 70, 129, 137 
DISTINCT ROLES FOR CALCIUM SIGNALING IN APOPTOSIS OF PROSTATE AND CERVICAL CANCER CELLS EXPOSED TO DIINDOLYLMETHANE
Carter, T., 36, 80 
Chakraborty, P.K., 90 
Chance, T.W., 54 
Chandel, N.S., 56 
NF-κB SUPER-INDUCTION: AN NF-κB MEMORY PATHWAY MEDIATED VIA THE EXCHANGE OF NF-κB DIMER SUBUNITS
Chang, P-Y.B., 39, 103 
H. PYLORI  SIGNALS THROUGH TLR2/9 TO INDUCE INVASIVENESS AND ANGIOGENESIS VIA COX-2 EXPRESSION: DIFFERENTIATION OF THE BINDING COMPONENTS OF CRE AND AP-1 ELEMENTS
Chang, Y-J., 43, 130 
CYCLOOXYGENASE 2 (COX-2) SUPPRESSES FORMATION OF ADHERENS JUNCTIONS AND STRESS FIBERS     
Chang, Y-W.E., 33, 54
Chen, C-C., 104, 130, 133 
MOLECULAR MECHANISM OF OPPOSITE REGULATION OF Inos AND COX-2 GENE EXPRESSION BY HMG-CoA INHIBITORS IN MURINE MACROPHAGES
Chen, J-C., 39, 104 
TRANSCRIPTIONAL REGULATION OF CYCLOOXYGENASE-2 PROTEASOME INHIBITOR MG132 INVOLVES CRE ELEMENT BINDING CCAAT/ENHANCER BINDING PROTEIN δ AND RECRUITMENT OF CBP
Chen, J-J., 39, 104
Chen, T., 89 
ENDOTHELIAL BARRIER DISRUPTION BY VEGF-MEDIATED SRC ACTIVITY POTENTIATES TUMOR CELL EXTRAVASATION AND METASTASIS
*Cheresh, D.A., 31, 125 
Chernoff, J., 55 
Cockett, M.I., 121 
SIGNAL TRANSDUCTION PATHWAYS ACTIVATED BY PATHOGENIC INFECTION AS THE TARGETS FOR ANTI-INFLAMMATORY DRUGS
*Cohen, P., 29, 100 
Corvinus, F., 58 
THE NUCLEOCYTOPLASMIC SHUTTLING OF PAK5 INFLUENCES ITS EFFECTS ON APOPTOSIS
Cotteret, S., 33, 55 
Courey, A.J., 68 
Courtneidge, S.A., 25, 54 
ACTIVITY-BASED PROTEIN PROFILING: CHEMICAL APPROACHES TO CANCER RESEARCH
*Cravatt, B.F., 31, 112 
Crowley, J.E. 
THE SRC-FAMILY KINASE YES HAS A SELECTIVE ROLE IN THE REGULATION OF CELL-CELL ADHESION IN COLON CARCINOMA CELLS
Cruzalegui, F. 
Cui, J., 125 
Curto, J.J., 59 

D

Dabul, L., 83 
Dahlgren, B., 94 
Davis, R.J., 56 
Dayan, F., 45 
THE SMALL GTPASE RAL MEDIATES B CELL ANTIGEN RECEPTOR-INDUCED GENE TRANSCRIPTION
De Gorter, D.J.J., 36, 81 
REGULATION OF ADHESION, SIGNALING AND ANGIOGENESIS BY INTEGRIN-LINKED KINASE (ILK)
*Dedhar, S., 31, 126 88, 93, 131 
Defeo-Jones, D., 79 
Degerman, E. 
de la Pompa, J.L. 
Delattre, O., 92 
Desimone, J., 120 
NOTCH PROMOTES EPITHELIAL-MESENCHYME TRANSITION IN HEART DEVELOPMENT AND TUMOR PROGRESSION
Diez, J.
Dilanchian, P. 
TARGETING THE MEVALONATE PATHWAY INHIBITS THE FUNCTION OF THE EPIDERMAL GROWTH FACTOR RECEPTOR: SYNERGISTIC CYTOTOXICITY INDUCED BY LOVASTATIN AND GEFITINIB
Dimitroulakos, J., 40, 114 
Djiane, J., 117 
SIGNALING PATHWAYS INVOLVED IN RAS ONCOGENE INDUCED CELL TRANSFORMATION
*Downward, J., 24, 53 
Drucker, C., 82 
Dunne, B. 

E

GLOBAL QUANTITATIVE ANALYSIS OF PROTEIN PHOSPHORYLATION STATUS IN FISH EXPOSED TO MICROCYSTIN
Edery, M., 40, 115 
THE ROLE OF TYPE 1 TYROSINE KINASE RECEPTORS IN HORMONE REFRACTORY PROSTATE CANCER
Edwards, J. 1 of 2 
THE ROLE OF THE PI3K/AKT CASCADE IN HORMONE REFRACTORY PROSTATE CANCER
Edwards, J. 2 of 2 
NOVEL GLYCOGEN SYNTHASE KINASE-3 INHIBITORS FOR  TREATMENT OF INSULIN RESISTANCE AND TYPE 2 DIABETES
Eldar-Finkelman, H., 40, 116 
MITOCHONDRIAL ROS ACTIVATION OF p38 MAPK IS REQUIED FOR HYPOXIA SIGNALING
Emerling, B.M., 33, 56 
GROWTH CONTROL BY ACTIVIN C IN LIVER CELLS
Erlach, N., 36, 82 63,
Errington, T.M., 84
Evans, J., 80 
HIGH-THROUGHPUT SCREENING FOR SMALL MOLECULE INHIBITORS OF THE Gα13/RHO SIGNALING PATHWAY
Evelyn, C. 

F

RHO GTPASES AND PROSTATE CANCER PROGRESSION
Faysal, J.M., 33, 57 
Fens, M.H.A.M., 133 
Ferrier, R., 59 
INTEGRIN-LINKED KINASE IS REQUIRED FOR ACTIVATION OF CDC42 AND RAC GTPASES
Filipenko, N.R., 42, 131 
Fischer, E.H., 27 
Fitzgerald, K., 121 
Francois, J.C., 115 
Friedl, P., 66 
PERSISTENT STAT3 ACTIVITY IN COLORECTAL CANCER CELLS IS TRIGGERED BY AN AUTOCRINE LOOP AND DRIVES CELL PROLIFERATION AND INVASIVENESS
Friedrich, K., 33, 58 
Frost, P., 78 
Frye, J., 36, 83 
Fujita, D.J. 

G

Galizzi, P. 
Gallyas, F., 105 
Ganjei-Azar, P., 129 
SIMULTANEOUS DETECTION OF MULTIPLE PHOSPHOPROTEIN TARGETS FROM HUMAN TUMOR TISSUES USING A SUSPENSION BEADS ASSAY SYSTEM
Gao, Q., 40, 116 
Gao, T., 50 
Gao, Y.J., 89 
Gaydos, C., 78 
NUCLEAR FUNCTIONS OF IKKalpha
*Gaynor, R.B., 30, 100 
SUPPRESSION OF PROSTATE CANCER METASTASIS BY SSeCKS/GRAVIN/AKAP12 CORRELATES WITH ANGIOGENESIS INHIBITION
Gelman, I.H., 42, 132 
Gerner, C., 82 
LARGE-SCALE PREPARATION OF NOVEL LEPTIN ANTAGONISTS BY SITE-DIRECTED MUTAGENESIS OF LEPTIN SITE III: IMPLICATIONS ON UNDERSTANDING AN ACTIVATION OF LEPTIN:LEPTIN RECEPTOR COMPLEX
Gertler, A., 40, 117 
THE MAMMALIAN TARGET OF RAPAMYCIN (MTOR) AS A TARGET FOR CANCER CHEMOTHERAPY
*Gibbons, J.J., 27, 78 
Gillman, A.G., 21, 45 
Ginouves, A., 45 
Gish, J., 85 
Glasman, M., 106 
Gonen-Berger, D., 117 
Goretzki, L., 130 
Goss, G., 114 
Gottardis, M.M., 121 
TRANSFORMATION OF NON-HEMATOPOIETIC CELLS BY IMMUNORECEPTOR TYROSINE-BASED ACTIVATION MOTIFS
Grande, S.M. 
Grego-Bessa, J. 
Grusch, M., 63, 82 
B-RAF IS CRITICAL FOR REGULATING MAPK SIGNALING AT MITOSIS
Guadagno, T.M., 33, 58 
Guigal, N. 
Gusterson, B., 59 

H 

REDUCTION OF RAF-1 KINASE INHIBITOR PROTEIN (RKIP) EXPRESSION IN BREAST CANCER METASTASES
Hagan, S., 33, 59
MONITORING SITE-SPECIFIC PROTEIN PHOSPHORYLATION: COMPARISON OF WESTERN BLOTTING AND BIO-PLEX
Han, H., 40, 117
INTRODUCTION TO THE ANTIBODY DATABASE FROM THE ALLIANCE FOR CELLULAR SIGNALING: TABULATION OF OUR EXPERIENCE WITH COMMERCIALLY AVAILABLE ANTIBODIES
Han, H., 40, 118
Hancock, P., 79 
Hanson, J.E.L., 114
Hanto, K., 105 
DISCOVERING NEW DRUG TARGETING SITES ON FLEXIBLE MULTI-DOMAIN PROTEIN KINASES
*Harris, T.K., 31, 111
Haskell, K., 79 
DYNAMIC ANALYSIS OF ERBB SIGNAL TRANSDUCTION PATHWAYS
Hatakeyama, M.
CLINICAL SEGMENTATION AND SIGNAL TRANSDUCTION IN CANCER
Hauser, F.E., 33, 60
Hecht, S.M., 84 
Henderson, J.E., 89
ANTI-EMETIC STEROID-COTREATMENT INDUCE RESISTANCE OF SOLID TUMORS TO CYTOTOXIC THERAPY
Herr, I., 41, 119
Hickman, J.A. 
Hindley, A.D., 71
Hirokawa, Y., 64 
Kos1, A NOVEL NONRECEPTOR TYROSINE KINASE, NEGATIVELY REGULATES CELL GROWTH BY RETARDING CELL CYCLE PROGRESSION
Hoare, K.
REGULATORY ROLE OF CK2 DURING THE PROGRESSION OF CELL CYCLE
Homma, M.K., 33, 60
Homma, Y., 60 
Honda, R., 75
FROM COMPLEXITY TO WHAT REALLY MATTERS: CONTROL OF MAPK SIGNALING
Hornberg, J.J.
Holst, L.S. 
Huang, W., 106
Huang, W-C., 104 
AKT INHIBITORS AS CHEMOSENSITIZERS
*Huber, H.E., 27, 79
Hunter, J.B., 68 
THE ERBB FAMILY OF RECEPTOR TYROSINE KINASE AND TUMOR CELL BIOLOGY
*Hynes, N.E., 31, 128 

I

MOLECULAR TARGETS FOR FGF SIGNALING IN BREAST CANCER
Ismail, A., 34, 61 

J

Jacob, R. 
Jakobi, R., 54 
Jakus, P., 105 
Janssen, A.P.C.A., 133 
P38-DEPENDENT REGULATION OF INFLAMMATORY GENE EXPRESSION IN RHEUMATOID ARTHRITIS
Jeon, S.J. 
ACTIVITY-BASED PROTEIN PROFILING OF HUMAN BREAST CANCER
Jessani, N. 
Jiang, X., 96 
REGULATION OF STEADY-STATE LEVELS OF HEMATOPOIETIC CYTOKINE RECEPTORS THROUGH UBIQUITINATION
Jing, X., 36, 83 
PROTEIN KINASE SUBSTRATE RECOGNITION AND REGULATION
*Johnson, L.N., 26, 75 
Jones, R., 79 
Jozwik, C., 106 
Jurecic, R., 83, 95 

K

Kadanovich-Beilin, O., 116 
ROLE OF PHO FAMILY GTPASES IN REGULATION OF CELL MIGRATION AND POLARITY
*Kaibuchi, K., 24, 51 
Kakkis, M., 41, 120 
THE IkB KINASE (IKK) AND THE CONTROL OF IMMUNITY, INFLAMMATION AND CANCER
*Karin, M., 30, 102 
BOTH NUCLEAR-CYTOPLASMIC SHUTTLING OF THE DUAL SPECIFICITY PHOSPHATASE MKP-3 AND ITS ABILITY TO ANCHOR MAP KINASE IN THE CYTOPLASM ARE MEDIATED BY A CONSERVED NUCLEAR EXPORT SIGNAL
Karlsson, M. 
USE OF A SMALL PEPTIDE TO INHIBIT THE INTERACTION OF IMMUNO-RECEPTOR TYROSINE-BASED ACTIVATION MOTIFS WITH SYK
Katz, E. 
A COMPARISON OF THE PROPERTIES OF NORE1A AND RASSF1A TUMOR SUPPRESSORS
Khohklatchev, A.V., 36, 83 
Kim, C.A., 68 
THE ROLE OF AKT IN HORMONE RESISTANT BREAST CANCER
Kirkegaard, T. 
Knight-Krajewski, S., 57 
Knowles, J., 120 
Kok, R.J., 136 
Kolch, W., 59, 71 
Koniaris, L.G., 65 
Kramer, R.A., 121 
Krebs, E.G., 27 
Krishnan, G., 100 
CORTACTIN TYROSINE PHOSPHORYLATION ENHANCES LAMELLIPODIUM FORMATION IN PANCREATIC CANCER CELLS
Kruchten, A.E., 34, 62 
Krueger, E., 62 
Kuldo, J.M., 122 
Kunzevitzky, N., 95 
Kyriakou, S., 94 

L

Lagarde, A.E., 114 
MULTIPLEX PHOSPHOANTIBODY-BASED ARRAYS: A NOVEL PLATFORM FOR PHOSPHOPROTEOMIC APPLICATIONS
Lakkis, M., 41, 120 
Lankelma, J. 
IDENTIFICATION OF THE FIRST SPECIFIC INHIBITOR OF p90 RIBOSOMAL S6 KINASE (RSK) REVEALS AN UNEXPECTED ROLE FOR RSK IN CANCER CELL PROLIFERATION
Lannigan, D.A., 36, 84 
TRANSLATIONAL CONTROL OF CELL VIABILITY: A GENOME-WIDE STUDY OF eIF4E MEDIATED APOPTOSIS RESISTANCE
Larsson, O. 
Lattimore, S. 
Leander, K., 79 
Leung, P.C.K., 94 
Levchenko, A., 123 
Levitz, R., 118 
Lew, B., 73 
Li, A., 89 
Li, W., 89 
Liberman, Z., 116 
Lin, J-T., 130 
Lin, W-W., 104 
Lin, Y., 106 
ANTITUMOR EFFECT OF THALIDOMIDE ON HUMAN LUNG CANCER XENOGRAFT IMPLANTED IN NUDE MICE: POSSIBLE INVOLVEMENT OF ICAM-1
Lin, Y-C., 42, 133 
Lindsley, C.W., 79 
THE HUMAN COMPLEMENT OF SH2 DOMAIN PROTEINS
Liu, B.A., 36, 85 
Liu, Y., 132 
Lockhart, B.P. 
Lolli, G., 75 
Loomis, A.K., 68 
DISCOVERY AND CHEMICAL VALIDATION OF NOVEL THERAPEUTIC TARGETS IN KEY TUMOR SUPPRESSOR AND ONCOGENE SIGNALING PATHWAYS
Lorenzi, M.V., 41, 121 
Lorimer, I.A., 114 
BLOCKAGE OF EGFR AND erbb2 SIGNALING AND ITS ROLE IN
HEPATOMA CELLS
Losert, A., 34, 63 
Lowe, E.D., 75 
MTOR AS A THERAPEUTIC TARGET FOR RADIATION SENSITIZATION OF GLIOMA VASCULATURE
Lu, B. 
Lucas, J., 78 
Lucci, J., 129 

M

TRYPTOPHANYL-tRNA SYNTHETASE AS A TARGET OF PHOSPHORYLATION BY PROTEIN KINASE OF CANCER SERUM
Malinovskii, V., 36, 85 
Mallon, E., 59 
SPECIFIC NUCLEAR ANCHORING OF ERK2 BY THE INDUCIBLE DUAL-SPECIFICITY MAP KINASE PHOSPHATASE DUSP5
Mandl, M. 
Mantha, A.J., 114 
Marlin, J.W., 54 
STRUCTURAL DETERMINANTS INVOLVED IN INTERACTIONS BETWEEN CYCLIC NUCLEOTIDE PHOSPHODIESTERASE 3B (PDE3B)
Manganiello, V. 
SMALL GTPASE SIGNALING PATHWAYS IN TUMOR CELL MOTILITY AND INVASION
*Marshall, C.J., 24. 49 
SIGNAL THERAPY OF CANCERS: BLOCKING PAK PATHWAYS BY FK228
aruta, H., 34, 64 
Mawji, N.M., 93 
Mazure, N., 45 
McDonald, P., 93 
ROLE OF N-RAS IN HORMONE RESISTANT BREAST CANCER
McGlynn, L.M. 
INTERLEUKIN-6 (IL-6) INHIBITS CELL GROWTH AT THE G1/M INTERPHASE IN HEPATOCELLULAR CARCINOMA
McKillop, I.H., 34, 65 
McNiven, M.A., 62 
Means, A.R., 73 
THE XIPHOPHORUS RECEPTOR TYROSINE KINASE XMRK CAUSES PIGMENT CELL MIGRATION  BY CONTROLLING THE ACTIVITY OF FOCAL ADHESION PROTEINS
Meierjohann, S., 34, 66 
Mezhoud, K., 115 
Michl, P. 
Miller, D., 94 
A UNIQUE CONTRIBUTION OF HEAT SHOCK TRANSCRIPTION FACTOR 4 IN OCULAR LENS DEVELOPMENT AND FIBER CELL DIFFERENTIATION
Min, J-N., 37, 86 
Mivechi, N.F., 86 
Miyamoto, S., 103 
MEASURING COMPLEX IN VIVO ENDOTHELIAL CELL RESPONSES: AN ESSENTIAL TOOL TO COMPREHEND THE DIFFERENCE BETWEEN THERAPEUTIC SUCCESS AND FAILURE
Molema, G., 41, 122 
TUMOR INHIBITION BY VASCULATURE SPECIFIC DELIVERY OF siRNA OR DOXORUBICIN USING RGD-TARGETED DRUG CARRIERS
Molema, G., 42, 133, 136 
COMBINING SIGNAL TRANSDUCTION INHIBITORS AS POTENTIAL TREATMENTS FOR MELANOMA
Molhoek, K.R., 37, 87 
Monroe, J.G. 
Monticello, D.J., 68 
Moorlag. H.E., 136 
Moran, D.M., 65 
Morel, M., 89 
DMYC TRANSFORMS CELLS INTO SUPER-COMPETITORS
Moreno, E., 34, 67 
Moriggl, R., 58 
Moshnikova, A., 36, 83 
Moskophidis, D., 86 
Mulla, F.A., 59 
Muller, B.M. 
Mumby, S.M., 117, 118 
Munro, A.F. 
Murali, R. 

N 

Nachtman, R., 95
Nakajima, H., 64 
Nash, P., 85
Nebreda, A.R., 56 
Neubig, R.
Newton, A., 50 
Nicke, B.
Niessen, S. 
Nilsson, R.
Niv-Spector, L., 117 
Noritake, J., 51 

O

PROTEASOME INHIBITOR-INDUCED APOPTOSIS IN MULTIPLE MYELOMA CELLS INVOLVES ENDOPLASMIC RETICULUM STRESS AND THE UNFOLDED PROTEIN RESPONSE
Obeng, E.A., 37, 88
COMBINING TARGETED AGENTS AGAINST CELL SIGNALING COMPONENTS INVOLVED IN CANCER: BETA-LACTAMASE’S ROBUSTNESS AND VERSATILITY AS A FUNCTIONAL CELL-BASED REPORTER
O'Grady, M.
Oien, K., 59 
INTEGRIN-LINKED KINASE FUNCTIONS AS AN INTERMIDIATE REGULATOR IN WNT3A-INDUCED STABILIZATION OF β-CATENIN
Oloumi, A., 37, 88
O’Neill, E., 71 
Oxley, D., 98
REGULATION OF THE POLARITY PROTEIN PAR6 BY THE TGFB RECEPTOR CONTROLS EPITHELIAL CELL PLASTICITY
Ozdamar, B., 34, 69

Paley, E.L., 85
Pals, S.T., 81 
Pardo, O.
Park, K-J., 100 
MODULAR PROTEIN INTERACTIONS IN SIGNAL TRANSDUCTION
*Pawson, T., 23, 48, 85
Pelech, S., 94 
Perez, A., 137
Peter-Vorosmarty, B., 63, 82 
CO-EXPRESSION OF ACTIVATED NRAS AND BRAF ONCOGENES IN MELANOMA CELLS IMPACTS ON HLA CLASS I ANTIGEN PROCESSING COMPONENTS PROFILE
Petti, C.
Pfitzner, E., 58 
PROTEIN ENGINEERING FOR EGFR ANTAGONISTS
Pienkos, P.T., 34, 68
Pirrett, C. 
Platanias, L.C., 56
Plotkin, B., 116 
Poelstra, K., 136
WNT SIGNALING AND BREAST CANCER
*Polakis, P.G., 26, 74
Pollard, H.B., 106 
GONADOTROPINS IN THE REGULATION OF CADHERIN-MEDIATED SURVIVAL SIGNALS OF OVARIAN SURFACE EIPTHELIUM
Pon, Y.L., 43, 134
Poteet-Smith, C.E., 84 
TUMOR ANGIOGENESIS VIA ERK AND HYPOXIA SIGNALING
*Pouyssegur, J., 23, 45
Praseult, D., 115 
Prieur, A., 92 

Q

DEREPRESSION
BY DEPOLYMERIZATION: STRUCTURAL INSIGHTS INTO THE REGULATION OF YAN BY MAEQiao, F., 23, 68

R

Rabinowitz, D., 80 
Radnai, B., 105 
Raha, S., 90 
Raina, M., 85 
MUC4 REGULATION OF ERBB2/ERBB3 SIGNALING
Ramsauer, V.P., 35, 70 
A NOVEL PATHWAY FOR STAT3 ACTIVATION
Raptis, L., 43, 135 
Reagan, K., 120 
Rebay, H., 68 
MICE LACKING THE SRC SUBSTRATE SAM68 ARE PROTECTED FROM AGE-RELATED BONE LOSS
Richard, S., 37, 89 
Robinson, R., 79 
Rong, M., 137 
Roskelley, C.D., 94, 131 
Roux, D., 45 
Rupnow, B.A., 121 
B-RAF FORMS REGULATED HETERODIMERS WITH RAF-1
Rushworth, L.K., 35, 71 
Ryseck, R.P., 121 

S 

Saedi, M., 130
Salas, P.J.I., 70 
Sanglier, C.
Savino, J., 80 
Sawaya, M.R., 68
Scaria, P.V., 133 
Schaefer, E., 120
Schartl, M., 66 
Schiffelers, R.M., 133
Schulte-Hermann, R., 63, 82 
KINASE-TARGETED THERAPIES – EMPTY PROMISES OR PATH TO CURE?
*Sebolt-Leopold, J.S., 23, 47
TEA POLYPHENOL EPIGALLOCATECHIN 3-GALLATE REVERSES THE ANTI-APOPTOTIC EFFECTS OF LOWGRADE REPETITIVE STRESS THROUGH INHIBITION OF Akt AND NFkB SURVIVAL PATHWAYS
Sen, P., 37, 90
ACTIVATION OF MK5/PRAK BY THE ATYPICAL MAP KINASE ERK3 DEFINES A NOVEL SIGNAL TRANSDUCTION PATHWAY
Seternes, O.M.
Shah, K., 94 
Simonyi, K., 116
Sinkovits, R., 118 
Sivera, J.
Skamnaki, V., 75 
Skotnicki, J., 78
Slingluff, C.L., 87 
Smith, J.A., 84
Smith, T.S., 98 
Song, H., 68
Sorrells, L., 118 
Soto, P., 137
Spaargaren, M., 81 
Storm, G., 133
Su, B., 132 
Suen, C., 116, 117
Sumegi, B., 105 

T 

Tam, L.
DOWN-REGULATION OF WNT SIGNALING BY THE PROTEIN TYROSINE KINASE c-Src
Tang, P.L.
Tapodi, A., 105 
TARGETING OF THE VEGF-KINASE INHIBITOR PTK787 TO ANGIOGENIC VASCULATURE USING RGD-EQUIPPED ALBUMIN CARRIER MOLECULES
Temming, K., 43, 136
Ten Hagen, T.L.M., 133 
IMPORTANCE OF HYDROPHOBIC MOTIF INTERACTIONS IN THE ACTIVATION OF SGK3
Tessier, M., 37, 91
Theodoropoulos, G., 137 
THE ROLE OF MTOR/SGK IN DEVELOPMENT AND HUMAN DISEASE
*Thomas, G., 26, 77
Thompson, E.A., 99 
Timmerman, L.A.
EWS/FLI-1 SILENCING AND GENE PROFILING OF EWING CELLS REVEAL DOWNSTREAM ONCOGENIC PATHWAYS AND A CRUCIAL ROLE FOR REPRESSION OF IGFBP-3 AND DKK1
Tirode, F., 37, 92
Tonks, N.K., 31, 129 
Toral-Barza, L., 78
JUN KINASE INTERACTS WITH APAF1 AND INHIBITS CASPASE-9 ACTIVATIN INDUCED BY OXIDATIVE STRESS
Tran, T.H., 39, 105
Trastour, C., 45 
Traynor, P.
Tremblay, G., 89 
Tremblay, M.L., 89
PREFERENTIAL DEPENDENCE OF CANCER CELLS VERSUS NORMAL CELL FOR INTEGRIN-LINKED KINASE INDUCED PKB/AKT ACTIVATION AND CELL SURVIVAL
Troussard, A.A., 38, 93
Tsareva, S.A., 58 
RELA/p65 NF-κB SUBUNIT BINDS THE BAX GENE PROMOTER AND INHIBITS p73-INDUCED BAX TRANSCRIPTIONAL ACTIVATION IN T CELL LINES
Tuosto, L.
NUCLEOPHOSMIN-ANAPLASTIC LYMPHOMA KINASE ACTIVATES MAP KINASE PATHWAYS ELICITING TRANSCRIPTION OF AP-1
Turner, S.D., 35, 72 

V 

POLY (ADP) RIBOSE POLYMERASE (PARP) INHIBITORS INFLUENCE THE TAXOL INDUCED CELL DEATH IN CULTURED CELLS
Varbiro, G., 39, 105
Venot, V. 
CHEMICAL GENETIC ANALYSIS OF THE ORB6/NDR KINASE PATHWAY
Verde, F., 38, 94
Viloria-Petit, A., 69 
Vize, P.D.
Vogel, G., 89 
Vos, J.C.M., 81
LIM KINASE 1 COORDINATES MICROTUBULE DISASSEMBLY AND ACTIN POLYMERIZATION IN HUMAN ENDOTHELIAL CELLS
Voyno-Yasenetskaya, T.
Vultur, A., 135 

W 

Wade, S.M.
MICROFABRICATED TOOLS FOR STUDYING AUTOCRINE SIGNALING DYNAMICS IN TURMOR COLONY
Wang, C.J., 30, 123
Wang, H-R., 69 
Wang, J., 120
Wang, Q. 
VITAMIN D INHIBITS CANCER CELL PROLIFERATION THROUGH NUCLEAR EXCLUSION AND DECREASED ACTIVITY OF CYCLIN-DEPENDENT KINASE 2
Wang, Z., 35, 72
AN MS-BASED IMMUNOAFFINITY APPROACH FOR QUANTITATION OF PROTEIN EXPRESSION AND MODIVIDATION LEVELS
Warren, E., 31, 124
Watanabe, T., 51 
Webster, K.A., 105
Weis, S., 125 
Welsh, C., 57
Wende, E., 66 
Westerhoff, H.V.
Wiley, D., 94 
Wolf, K., 66
ERK1/2, PI3K AND p70S6K ARE IMPORTANT MEDIATORS FOR HGF-INDUCED MIGRATION AND INVASION IN HUMAN OVARIAN CANCER CELLS
Wong, A.S.T., 38, 94 134
Wong, T.W., 121 
Woodgett, J.R., 91
Woodle, M.C., 133 
Wrana, J.L., 69
Wu, M-S., 130 

X

Xu, M-J., 97 
Xu, Y., 84

Y

Yamamoto, Y., 100 
Yang, E.S., 72
Yang, F.T., 98 
PUM2 PROTEIN SUPPORTS MAINTENANCE AND SUPPRESSES DIFFERENTIATION OF MULTIPOTENT HEMATOPOIETIC PROGENITORS BY REGULATING THE FUNCTION AND ACTIVATION OF C-KIT RECEPTOR
Yang, J., 38, 95
Yang, M., 68 
INHIBITION OF TNF/NFκB SIGNALING PATHWAY BY DIGITOXIN AND RELATED CARDIAC GLYCOSIDES                                       
Yang, Q., 39, 106
Yasin, M., 129, 137 
IDENTIFICATION OF CYCLIN E AS A NOVEL PIN1 TARGET
Yeh, E.S., 35, 73
Yeung, D., 72 
THE ROLE OF TSC2/MTOR PATHWAY IN PROTEIN TRANSPORT
Yeung, R.S., 26, 38, 96
THE ROLE OF TSC2/mTOR PATHWAY IN PROTEIN TRANSPORT
Yeung, R.S., 26, 38, 96
Yu, K., 78 
Yuan, M. 

Z

A NEW MONOCLONAL ANTIBODY AGAINST MUC4β DEMONSTRATES THE PRESENCE OF MUC4 IN HUMAN MILK AND AT THE LUMINAL SURFACE OF BLOOD VESSELS
Zhang, J., 43, 137 
Zhang, W-G., 78 
Zhang, Y., 69, 86 
AN ONCOGENIC TYROSINE KINASE INHIBITS DNA REPAIR AND BCL-XL DEAMIDATION IN T CELL TRANSFORMATION
Zhao, R., 38, 98, 97 
Zhao, Z., 79 
CELL SURFACE PROTEIN PZR IS REQUIRED FOR NORMAL DEVELOPMENT OF LYMPHOCYTES
Zhao, Z.J., 38, 97 
Zhou, H.Y., 94 
Zhu-Shimoni, J., 117 
PPARγ/TGFβ CROSS-TALK IN THE INTESTINAL EPITHELIUM
Zies, D.L., 38, 99 
Zwiers, P.J., 122