2006 Proceedings

MOLECULAR  MECHANISMS  OF  ANGIOGENESIS

Invited Speakers
LYMPHANGIOGENESIS IN DEVELOPMENT AND HUMAN DISEASE
Kari Alitalo

SIGNALING PATHWAYS THAT CONTROL ANGIOGENESIS, GROWTH AND FUNCTION IN THE HEART
Kenneth Walsh

ANTIVASCULAR THERAPY OF CANCER METASTASIS
Isaiah J. Fidler

CONTRIBUTIONS OF ADHESION TO VASCULAR DEVELOPMENT
Richard O. Hynes

Posters
P70S6K MODULATES THE ANGIOGENIC EFFECTS OF ANGIOPOIETIN-1
Cao, Z. and Jian, B-H.

AN IMBALANCED EXPRESSION OF STEFIN A AND CATHEPSIN B IN VEGF 164-INDUCED MOTHER VESSELS
Chang, S.H., Zhao, J., Nagy, J., and Dvorak, H.F. 

RAC1 IS REQUIRED VESSEL MAINTENANCE BUT NOT DEVELOPMENTAL ANGIOGENESIS
D’Amico, G., Grose, R., Steen, K.T., Tybulewicz, V., Robinson, S.D. and Hodivala-Dilke, K.

1-A NOVEL PI3K/PLCγ1/Akt PATHWAY IN ANGIOGENESIS
Maffucci, T., Zachary, I. and Falasca, M. 

THE CLESH DOMAIN OF HISTIDINE-RICH GLYCOPROTEIN IS IMPORTANT FOR MODULATION OF THE TSP-1-CD36 ANTI-ANGIOGENIC PATHWAY
Klenotic, P.A., Febbraio, M. and Silverstein, R.L.

THE IDENTIFICATION AND CHARACTERIZATION OF NEAT, A NOVEL POTENTIAL REGULATOR OF ANGIOGENESIS
Ling, L., Voskas, D., Lhotak, V., Kim, H., Alitalo, A. and Dumont, D.J. 

AN ACTIVATING MUTATION IN THE PLATELET-DERIVED GROWTH FACTOR RECEPTOR-β CAUSES EXCESSIVE BLOOD VESSEL FORMATION AND PLACENTAL DEFECTS
Looman, C., Magnusson, P., Ahgren, A., Heldin, C., Fundele, R., Cleasson-Welsh, L. and Heuchel, R.

INVOLVEMENT OF CONNECTIVE TISSUE GROWTH FACTOR IN CAPILLARY-LIKE CORD FORMATION INDUCED BY SPHINGOSINE-1 PHOSPHATE
Markiewicz, M., Ka

anadze, B. and Trojanowska, M.
HEPARIN BINDING EGF-LIKE GROWTH FACTOR (HB-EGF) PROMOTES ENDOTHELIAL CELL WOUND HEALING AND ANGIOGENESIS VIA ACTIVATION OF THE PI3-KINASE PATHWAY
Mehta, V.B. and Besner, G.E.

REGULATION OF TISSUE FACTOR AND ANGIOGENESIS RELATED GENES BY CHANGES IN CELL SHAPE
Milsom, C.C. and Rak, J.

CORNEAL AVASCULARITY IS DUE TO SOLUBLE VEGF RECEPTOR-1
Nozaki, M., Raisler, B., Baffi, J., Takeda, A., Witta, J., deFalco, S., Shibuya, M., Ambati, B. and Ambati, J.

A MYC-TWIST-SLUG REGULATORY CIRCUIT DIRECTING NEURAL CREST DETERMINATION AFFECTS ANGIOGENESIS
Rodrigues, C.O., White, E.L., King, M.L., Bishopric, N. and Cleveland, J.L. 

CD13/APN REGULATES BRADYKININ INDUCED ENDOTHELIAL INVASION AND FILOPODIA FORMATION BY MODULATING MEMBRANE INTEGRITY
Petrovic, N., Schacke, W., Gahagan, J.R., Liu, X., Mina-Osorio, P. and Shapiro, L.H. 
SUCCINATE AND α-KETOGLUTARATE: A ROLE BEYOND THE KREBS CYCLE       
Sirinyan, M.A., Sennlaub, F. and Chemtob, S.

LACTADHERIN PROMOTES VEGF-DEPENDENT NEOVASCULARIZATION
Thery, C., Silvestre, J.S., Tedgui, A., Amigorena, S. and  Mallat, Z.

IQGAP1 MEDIATES VE-CADHERIN-BASED CELL-CELL CONTACTS AND VEGF SIGNALING AT ADHERENCE JUNCTIONS LINKED TO ANGIOGENESIS
Yamaoka-Tojo, M., Tojo, T., Kim, H.W., Patrushev, N.A., Fukai, T. and Ushio-Fukai, M.
SRC TYROSINE KINASE PHOSPHORYLATES VE-CADHERIN IN RESPONSE TO VEGF:  IDENTIFICATION OF THE TYROSINE 685 AS THE UNIQUE TARGET SITE
Wallez, Y., Cand, F., Cruzalegui, F., Souchelnytskyi, S., Huber, P. and Vilgrain, I.

ANGIOPOIETINS PROMOTE NEURITE OUTGROWTH IN NEURONAL CELLS IN VITRO
Tung, C.E. and Ward, N.L.
FORCE SPECTROSCOPY OF LFA-1 AND ITS LIGANDS
Wojcikiewicz, E.P., Abdulreda, M.H. and Moy, V.T.

DOWNREGULATION OF FLI1 IN HUMAN MICROVASCULAR ENDOTHELIAL CELLS PROMOTES CELL SURVIVAL AND LEADS TO CORD FORMATION IN 3D COLLAGEN GELS
Yamasaki, M., Kapanadze, B., Markiewicz, M. and Trojanowska, M.

REGULATION OF ERBB RECEPTOR ENDOCYTOSIS AND ITS IMPLICATIONS IN BREAST CANCER DEVELOPMENT
Wang, Z. and Chen, X.

ELUCIDATION OF THE MECHANISMS UNDERLYING THE ANGIOGENIC EFFECT OF GINSENOSIDE Rg₁ in vivo and in vitro
Yue, P.Y.K., Fan, D.T.P. and Wong, R.N.S.

SURVEY O MATRIX METALLPROTEINASES (MMPs) IN TUMOUR CELLS AND NORMAL FIBROBLASTS
Akpasi, N.A.

PLACENTA GROWTH FACTOR IS NOT ESSENTIAL FOR SPIRAL ARTERY MODIFICATION IN PREGNANT MICE
Fang, Y., Tayade, C., He, H., Hilchie, D., Moons, L., Carmeliet, P., Foster, R., and Croy, A.

ANGIOGENIC ACTIVITY OF SERUM AMYLOID A
Lee, M.S., Kim, W.U., Yoo, S.A. and Ryu, S.H.

MATERNAL LYMPHOCYTES AND ENDOMETRIAL ENDOTHELIUM ARE KEY REGULATORS OF THE ANGIOGENESIS THAT PROMOTES FETAL SURVIVAL
Tayade, C., Fang, Y. and Croy, A.

MODULATION OF THE BIOLOGICAL ACTIVITIES OF VEGF AND VEGF-C BY SWAPPING OF THE SILK AND HEPARIN-BINDING DOMAINS
Tammela, T., Keskitalo, S., He, Y., Lyytikka, J., Kunnapuu, J., Tatlisumak, T. Yla-Herttuala, S., and Alitalo, K.

EMODIN INHIBITS VASCULAR ENDOTHELIAL GROWTH FACTOR-A-INDUCED ANGIOGENESIS BY BLOCKING RECEPTOR-2 (KDR/FLK-1) PHOSPHORYLATION
Park, M.J., Kwak, H.J., Park, I.C., Rhee, C.H., Lee, K.H. and Hong, S.I.  

STEM CELLS AND VASCULAR REGENERATION

Invited Speakers

CXCR4 AND VEGF-RECEPTOR ACTIVATION PROVIDE FOR PERMISSIVE CONDITIONS TO ACCELERATE LUMINAL  INCORPORATION OF PRO-ANGIOGENIC HEMATOPOIETIC AND VASCULAR CELLS INTO THE NEO-ANGIOGENIC NICHE
Shahin Rafii

MECHANISM REGULATING ENDOTHELIAL PROGENITOR CELL HOMING AND DIFFERENTIATION
Stefanie Dimmeler 

COMBINATION CELL AND GENE THERAPY FOR PERIPHERAL ISCHEMIA USING MYOBLASTS AND STEM CELLS ENGINEERED WITH CONDITIONALLY SILENCED GENES
Keith Webster 

Posters 

PHENOTYPIC AND MICROARRAY ANALYSES OF HUMAN CIRCULATING ENDOTHELIAL PROGENITOR CELLS
Bourboulia, D., Martinez, D., Trotter, M., Yong, K. and Boshoff, C. 

MORPHOANGIOGENESIS:  A UNIQUE ACTION OF GROWTH HORMONE THAT PRODUCES RENESTRATED CAPILLARIES AND STEM CELLS
Dunn, A.R. 

IDENTIFICATION OF HUMAN FETAL AORTA-DERIVED VASCULAR PROGENITOR CELLS CAPABLE OF INDUCING VASCULOGENESIS AND ANGIOGENESIS IN VITRO AND IN A MURINE MODEL OF PERIPHERAL ISCHEMIA
Invernici, G., Emanueli, C., Gadau, S., Madeddu, P., Benetti, A., Stassi, G., Patti, M., Baronio, M., Nicosia, R., Peschle, C., Fascio, U., Colombo, A., Parati, E. and Alessandri, G.

INTRAVENOUS INFUSION OF HUMAN UMBILICAL CORD STEM CELLS 1 DAY AFTER MYOCARDIAL INFARCTION LEADS TO NEOVASCULARIZATION AND IMPROVES CARDIAC FUNCTION
Mal, N., DeLuca, K., Liebermann-Vinson, A., Xu, R., Porter, W., Popovic, Z., Forudi, F. and Penn, M. 

CULTURE EXPANDED ENDOTHELIAL PROGENITOR CELLS (CE-EPCS)
Sharpe, E.E., Teleron, A.A., Li, B., Price, J., Sands, M.S., Alford, K. and Young, P.P. 

VEGF PROMOTES ADULT VASCULOGENESIS BY ENHANCING EPC RECRUITMENT AND VESSEL FORMATION AT SITE OF TUMOR NEOVASCULARIZATION
Li, B., Sharpe, E.E., Teleron, A.A., Pyle, A., Carmeliet, P., Young, P.P.

DELIVERY OF VEGF₁₆₅ WITH HYPOXIA-REGULATED ADENO-ASSOCIATED VIRUS (AAV) SEROTYPE 9 PRODUCES STABLE CONDUCTION VESSELS IN MOUSE ISCHEMIC LIMBS 
Spiga, M.G., Layman, H., Wilson, A.D., Jia, Y., Bishopric, N.H., Andreopoulos, F.M. and Webster, K.A. 

ACTIVATED RAS SIGNALING INDUCES IMPROVED PROLIFERATION, ENGRAFTMENT AND PLASTICITY IN HUMAN CORD BLOOD CD343+
Knight, R.J.W.,  Shen, S.W., Passioura, T., O’Brien, T., Symonds, G., Lindemann, R. and Dolnikov, A. 

TUMOR ANGIOGENESIS AND VASCULAR DISEASE

 Invited Speakers 

TARGETING VEGF:  FROM BENCH TO BEDSIDE
Napoleone Ferrara

 
HOW TUMORS MAKE BAD BLOOD VESSELS
Harold F. Dvorak 

ENGINEERED ZINC FINGER PROTEINS - EDITORS OF GENOME SEQUENCE AND FUNCTION
Philip D. Gregory 

Posters 

AFM STUDIES ON BILAYER INTERACTIONS AND FUSION
Abdulreda, M.H. and Moy, V.T.

CARDIAC MYOCYTE p300 LEVELS REGULATE MYOCARDIAL ANGIOGENESIS
Pessanha, M., Wei, J.Q., Shehadeh, L., Faysal, J., Webster, K.A. and Bishopric, N.H.

ANGIOGENIC EFFECTS IN NORMAL BRAIN FOLLOWING PHOTODYNAMIC THERAPY ARE LIGHT DOSE DEPENDENT
Bisland, S.K., Linn, A. and Wilson, B.C. 

CHARACTERIZATION OF VEGF RECEPTOR TWO EXPRESSION IN THE RETINOBLASTOMA MOUSE MODEL LhβTag
Cebulla, C.M., Jockovich, M.E., Suarez, F. and Murray, T.G. 

SMOOTH MUSCLE CELL AND PERICYTE CHANGES UNDERLY PATHOGENESIS OF PLUS DISEASE IN RETINOPATHY OF PREMATURITY (ROP)
Hughes, S., Gardiner, T., Baxter, L. and Chan-Ling, T.

VEGF AND FGF-2 PARTICIPATION IN PITUITARY TUMORS OF DOPAMINERGIC D2 RECEPTOR (D2R) KNOCKOUT FEMALE MICE
Cristina, C., Gongora, A., Baldi, A., Diaz-Torga, G., Low, M.J. and Becu-Villalobos, D. 

LOSS OF PTEN INCREASES HIF-1 TRANSCRIPTIONAL ACTIVITY INDEPENDENT OF Akt/mTOR SIGNALING
Emerling, B.M. and Chandel, N.S. 

R-RAS IS A NEW REGULATOR OF VASCULAR REGENERATION THAT SUPPRESSES INTIMAL HYPERPLASIA AND TUMOR ANGIOGENESIS
Komatsu, M. and Ruoslahti, E. 

HEMORRHAGIC NECROSIS INDUCED BY ALPHA TUMOR NECROSIS FACTOR IN SOLID TUMORS
Loefflmann, A. 

SP600125 SELECTIVELY INHIBITS HISTONE H3-Ser10 PHOSPHORYLATION
Mehta, K.D., Huang, W., Batra, S. and Korrapati, S. 

α3β1-INTEGRIN-DEFICIENCY PROMOTES ANGIOGENESIS
Silva, R., Reynolds, L.E., Szekeres, K., Robinson, S.D., Lamar, J., DiPersio, C.M., Kreidberg, J.A., Saunders, G., and Hodivala-Dilke, K. 

SSeCKS METASTASIS-SUPPRESSING ACTIVITY CORRELATES WITH ANGIOGENESIS INHIBITION
Su, B., Zheng, Q., Vaughan, M.M., Bu, Y. and Gelman, I.H.  

VEGF EXPRESSION IS REGULATED BY NGF THROUGH trkA RECEPTORS IN EPITHELIAL OVARIAN CANCER
Campos, X., Weinstein-Oppenheimer, C., Tapia, V., Selman, A., Lara, H.E. and Romero, C.

MUC4 ASSOCIATION WITH FORMING BLOOD VESSELS DURING CORNEAL WOUND HEALING
Zhang, J., Carraway, C.A.C., Carraway, K.L.  

LYMPHANGIOGENESIS

Invited Speakers 

MOLECULAR PATHWAYS FOR LYMPHANGIOGENESIS AND THEIR ROLE IN HUMAN DISEASE
Steven A. Stacker 

ANGIOGENESIS AND LYMPHANGIOGENESIS IN INFLAMMATION AND CANCER
Michael Detmar

CELLULAR EFFECTS OF ANGIOGENESIS INHIBITORS ON BLOOD VESSELS
Donald M. McDonald 

ENDOGENOUS ANGIOGENESIS INHIBITORS: DO THESE MOLECULES SUPPRESS ANGIOGENESIS-DEPENDENT DISEASE?
Judah Folkman

Posters 

ROLE OF INTEGRINS DURING LYMPHANGIOGENESIS
Garmy-Susini, B. and Varner, J. 

HGF UPREGULATES VEGF-C EXPRESSION AND COOPERATES WITH VEGF-C DURING LYMPHANGIOGENESIS
Kloos, B.T. and Skobe, M. 

INHIBITION OF TUMOR GROWTH BY A SYNTHETIC COMPOUND BPR0L075 IS MEDIATED THROUGH SUPPRESSION OF TUBULIN POLYMERIZATION AND ANGIOGENESIS
Liu, K.J., Hung, Y.M., Liou, J.P. and Chang, J.Y. 

INTERFERON ALPHA AND BLEOMYCIN EXERT ANTIANGIOGENIC ACTIVITY THROUGH DIFFERENT MECHANISMS
Mabeta, P., Davis, P.F. and Pepper, M.S. 

EVIDENCE OF ANTIANGIOGENIC AND ANTIMETASTATIC ACTIVITIES OF THE RECOMBINANT DISINTEGRIN DOMAIN OF METARGIDIN
Trochon-Joseph, V., Renoir, D., Mir, L.M., Thomaidis, A., Opolon, P., Connault, E., Li, H., Grenet, C., Fauvel-Lafeve, F., Soria, J., Legrand, C., Soria, C., Perricaudet, M. and Lu, H. 

A NOVEL DUAL-TARGETING DRUG FOR SOLID TUMORS AND THEIR VASCULARTURE
Wu, J.J., Garde, S., Lepekhin, E., Forte, A., Ge, M., Stranix, B., Pelletier, I., Dulude, H., Daigneault, L. and Panchal, C. 

ANGIOGENESIS INHIBITION 

Invited Speakers 

LESSONS FROM PHASE III CLINICAL TRIALS ON ANTI-VEGF THERAPY FOR CANCER
Rakesh K. Jain, Dan G. Duda, Jeffrey W. Clark and jay S. Loeffler
Review from Nature Clinical Practice Oncology, January 2006, Vol. 3, No. 1
www.nature.com/clinicalpractice/onc

COMBINATORIAL MAPPING OF MOLECULAR ADDRESSES IN CANCER AND VASCULAR DISEASE
Renata Pasqualini and Wadih Arap 

PRECLINICAL AND CLINICAL STUDIES OF LOW DOSE METRONOMIC (ANTIANGIOGENIC) CHEMOTHERAPY FOR TREATMENT OF ADVANCED METASTATIC DISEASE
Robert S. Kerbel 

Posters

BIRM, AN ANDEAN PLANT EXTRACT, DOWN REGULATES ANDROGEN RECEPTOR AND SHOWS ANTI-TUMOR ACTIVITY IN PROSTATE CANCER
Araki, S., Lyn, D. and Lokeshwar, B.L. 

SULFORAPHANE INDUCES INHIBITION OF HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS PROLIFERATION BY APOPTOSIS
Asakage, M., Tsuno, N.H., Takahashi, K. and Nagawa, H. 

MEK/MAPK SIGNALING IN GROWTH AND VASCULARIZATION OF KAPOSI’S SARCOMA
Depeille, P., Young, J.J., Boguslawski, E. and Duesbery, N.S. 

DEFIBROTIDE, AN ENDOTHELIUM STABILIZING DRUG, HAS ANTI-ANGIOGENIC PROPERTIES IN VITRO AND IN VIVO       
Koehl, G.E., Geissler, E.K., Frei, C., Iacobelli, M., Burger, V., Haffner, S., Holler, E.,
Andreesen, R. and Eissner, G.

EXEL-2880, A SMALL-MOLECULE, ORALLY AVAILABLE TYROSINE KINASEINHIBITOR  HAT TARGETS VEGFR AND THE HGF RECEPTOR, C-MET. POTENT ANTI-ANGIOGENIC AND ANTI-TUMOR EFFECTS IN VITRO AND IN VIVO
Joly, AH. and Gerritsen, M.E. 

ENHANCED ANTI-ANGIOGENIC EFFECT OF COMBINATION THERAPY TARGETING VEGFR AND PDGFR IN TUMORS DISPLAYING VESSELS WITH HIGH PERICYTE COVERAGE
Hasumi, Y., Klosowska-Wardega, A., Heldin, C.H., Ostman, A. and Hellberg, C.

ANGIOGENESIS-DEPENDENT PROCESSES UNDER EXPOSURE TO HYPOXIA AND PERSPECTIVES FOR THE DEVELOPMENT OF HYPOXIC THERAPY
Koulich-Sutton, O.P. and Strelkov, R.B. 

ENDOSTATIN DIMER STABILITY AND ITS IMPLICATIONS FOR CANCER THERAPY 
Limaverde, G.S.C.S., Lopez, L.B., Giordani-Duarte, A.C., Costa, M.G.S., Cinelli, L.P., Medeiros, L.N., Kurtenbach, E., Coelho-Sampaio, T. and Pascutti, P.G.

MULTIPLE ANTIANGIOGENIC INHIBITORS IN A SINGLE LEAF EXTRACT
Liu, Z. and Woltering, E.A. 

THE ANTI-ANGIOGENIC ACTIVITY OF VEGF-A IS MASKED BY THE SILENCING OF VEGFR-1 BY SPARC
Raisler, B., Nozaki, M., Baffi, J., Brekken, R., Sage, E.H., Ambati, J.

THROMBOSPONDIN TYPE 1 REPEAT (TSR) OF HUMAN ADAMTS4 FUNCTIONS AS AN ANTIGENIC INHIBITOR BY INFLUENCING MULTIPLE ASPECTS OF ANGIOGENESIS
Rajesh, M., Potturi, P., Wang, Z., Yang, H. and Ge, R. 

MECHANISM OF INHIBITION OF PERITONEAL ANGIOGENESIS BY BUTYRATE IN EAT BEARING MICE IS MEDIATED BY SP1 TRANSCRIPTION FACTOR
Salimath, B.P., Thippeswamy, G., Prabhakar, B.T., Prasanna Kumar, S. and Sheela, M.L.

TUMOR PERFUSION DURING TREATMENT WITH SU11248 (SUNITINIB MALATE) IN PATIENTS WITH ADVANCED MALIGNANCIES AS ASSESSED BY (OXYGEN-15)-WATER PET IMAGING
Scott, A.M., Mitchel, P., O’Keefe, G., Saunders, T., Hicks, R.J., Poon, A., Baum, C., Brega, N., McCarthy, T. and Toner, G. 

VEGF ₁₆₅b CAN INHIBIT COLORECTAL CANCER GROWTH IN VIVO
Varey, A.H.R., Rennel, E.S., Dixon, A.R., Harper, S.J. and Bates, D.O.

STRUCTURE-BASED DESIGN OF VEGF RECEPTORS ANTAGONISTS
Goncalves, V., Inguimbert, N., Garbay, C. and Vidal, M. 

ACTIVE IMMUNIZATION AGAINST VASCULAR ENDOTHELIAL CELLS INHIBITS TUMOR ANGIOGENESIS AND METASTASIS
Yoneyama, S., Tsuno, N.H., Takahashi, K. and Nagawa, H.    

EMERGING  TECHNOLOGIES 

Invited Speakers 

ENGINEERING VESSELS: PROBLEMS AND CONSIDERATIONS
Laura E. Niklason

AN ANTI-VEGF APTAMER FOR OCULAR DISEASE
Anthony P. Adamis 

INTEGRIN ALPHA 3 BETA 1-MEDIATED SUPPRESSION OF TUMOR ANGIOGENESIS—A NOVEL THERAPEUTIC APPROACH
William G. Stetler-Stevenson 

PROTEOMIC MAPPING AND IMAGING OF ENDOTHELIUM AND ITS CAVEOLAE TO IDENTIFY ACCESSIBLE IMMUNOTARGETS FOR SPECIFIC PENETRATION INTO SOLID TUMORS AND MAJOR ORGANS
Jan E. Schnitzer 

Posters 

THE SHELL-LESS CHIC CAM (CHICKEN CHORIOALLANTOIC MEMBRANE) ASSAY:  A MODEL FOR STUDYING MELANOMA ANGIOTROPISM AND EXTRAVASCULAR MIGRATORY METASTASIS
Lugassy, C., Vernon, S.E. and Barnhill, R.L. 

SYNERGETIC EFFECT OF STROMAL CELL-DERIVED FACTOR-1 AND GRANULOCYTE COLONY STIMULATING FACTOR ON NEOVASCULARIZATION
Tan, Y., Shao, H., Yang, Z., Alonso-Diaz, L., Eton, D and Yu, H.

CASPASE ACTIVATION INDUCED MICROVESSEL DISRUPTION
Dong, Z., Song, W., Zeitlin, B.D. and Nor, J.E. 

A DNA VACCINE TARGETING THE ANGIOSTATIN RECEPTOR ANGIOMOTIN INHIBITS ANGIOGENESIS AND SUPPRESSES TUMOR GROWTH
Holmgren, L., Ambrosino, E., Tullus, C., Forni, G., Cavallo, F. and Kiessling, R.

THE CXCR4 ANTAGONIST CTCE-9908 INHIBITS SDF-1-INDUCED ANGIOGENESIS
Leung, E., Merzouk, A., Salari, H. and Abramovich, C. 

ENDOTHELIAL PROGENITORS INCRASE TUMOR GROWTH RATE AND MODIFY TUMOR PHYSIOLOGY: POTENTIAL THERAPEUTIC TARGETS
Williams, B.W., Dudek, A., Hebbel, R. and Griffin, R.

INDUCTION OF APOPTOSIS BY RESVERATROL IN CANCER CELLS DURING COMBINATION TREATMENT WITH NUTLIN-3 AND TGF-β
Kaur, K., Pervez, F.F., Jasani, V., Bukhari, N., Narasimhan, M., and Rathinavelu, A.    

THERAPEUTIC  ANGIOGENESIS

Invited Speakers

MOLECULAR MECHANISMS AND THERAPEUTIC ANGIOGENESIS STRATEGIES
Michael Simons

NEURAL GUIDANCE RECEPTORS IN ANGIOGENESIS
Anne Eichmann 

NEUROTROPHINS IN THERAPEUTIC ANGIOGENESIS: DISTINCT ACTIONS IN LOCAL ENDOTHELIAL CELL RECRUITMENT AND IN SYSTEMIC MOBILIZATION OF HEMATOPOIETIC PROGENITORS
Barbara L. Hempstead 

WHY ARE THERE NO THERAPEUTIC PRO-ANGIOGENIC AGENTS ON THE MARKET?
J. Anthony Ware 

Posters

EVALUATION OF NOVEL GLYCOCONJUGATE MOLECULES AS PROMISING ANTI-CANCER AGENTS
Faried, A., Faried, L.S., Hashimoto, S., Tsuboi, K., Asao, T., Kuwano, H. and Yazawa, S. 

AN αVβ3 AND α5β1 INTEGRIN ANTAGONIST PEPTIDE THAT INHIBITS TUMOR GROWTH ALSO REDUCES SCAR FORMATION AND REVERSES CHOROIDAL NEOVASCULARIZATION
Ponce, M.L., Wolfe, J., Kleinman, H.K. and Csaky, K.G.

CONCENTRATION OF SOLUBLE VEGF-R1 AND VEGF-R2 IN EXTRAEMBRYONIC CELOMIC FLUID IN PRIMATES
Santolaya-Forgas, J., Wolf, R., Edwin, S., Pitt, A., Nien, J.K. and Romero, R. 

CCI-779 INHIBITS RHABDOMYOSARCOMA XENOGRAFT GROWTH BY AN ANTIANGIOGENIC MECHANISM LINKED TO TARGETING mTOR/Hif-1α/VEGF SIGNALING
Wan, X., Shen, N., Harkavy, B., Mendoza, A. and Helman, L.J.

GENETIC HETEROGENEITY OF HYPOXIA INDUCED ANGIOGENESIS AND ITS MOLECULAR MECHANISMS IN THE BRAIN
Ward, N.L., Moore, E., Noon, K., Spassil, N., Sun, X., Blankenship, D.A. and LaManna, J.C. 

NOVEL SMALL MOLECULE INDUCER OF ANGIOGENESIS STIMULATES IN VITRO WOUND HEALING
Wieghaus, K.A., Brown, M.L. and Botchwey, E.A.

EXPLORING TUMOR-ASSOCIATED VASCULOPATHY IN CANCER PATIENTS TREATED WITH AN AUTOLOGOUS TUMOR CELL VACCINE
Schoenfeld, J., Wiener, D., and Dranoff, G. 

NOVEL ENDOTHELIAL ADHESION ASSAYS TO MEASURE INTEGRIN-MEDIATED LEUKOCYTE ACTIVATION  
Jagow, C., Asbrock, N., Chu, V., Borree, T., Schneider, P., Radany, B., Hsu, M.

ANALYSIS OF THE INTERACTION OF ADHESION AND GROWTH FACTOR INITIATED SIGNAL TRANSDUCTION DURING ANGIOGENESIS     
Seehra, K.K., Shaw, P.E., Leach, L. and Jones, P.